Post-Doctoral Fellow

2007—2011
Email Address: abdelmagid@email.chop.edu

Is a graduate from Ain Shams University, School of Medicine, Cairo, Egypt (M.D.), and Ph.D. from Temple University School of Medicine, Philadelphia, PA, who is currently studying gene mutation in human ANK leading to Craniometaphyseal Dysplasia characterized by abnormal bone modeling. He is working to identify the role of pyrophosphate ions, transported by ANK protein, in osteoclast differentiation and activebone resorption. Understanding the pathological effects resulted from mutated ANK protein on bone modeling stimulating osteoblast differentiation and/ or inhibiting osteoclastogenesis may elucidate new therapeutic modalities in the controlling susceptibility to common mineral deposition diseases.

Publications:
Peer Reviewed Publications:

  1. Abdelmagid SM, Barbe MF, Rico MC, Salihoglu S, Selim AH, Arango-Hisijara I, Anderson MG, John SW, Owen TA, Popoff SN, Safadi FF. Osteoactivin, an Anabolic Factor that Regulates Osteoblast Differentiation and Function. Journal of Experimental Cell Research, 2008
  2. Barbe MF, Elliott MB, Abdelmagid SM, Safadi FF, Popoff SN, Amin M, Barr AE. Serum and Tissue Cytokines and Chemokines Increase with Performance of Repetitive Upper Extremity Tasks. Journal of Orthopaedic Research, 2008
  3. Kominsky SL, Abdelmagid SM, Doucet M, Brady K, and Weber KL. MIP-1δ: a Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis. Journal of Cancer Research, 68:1261-1266, 2008
  4. Abdelmagid SM, Barbe MF, Arango IA, Owen TA, Popoff SN, Safadi FF. Osteoactivin Acts as Downstream Mediator of BMP-2 Effects on Osteoblast Function. Journal of Cellular Physiology, 210:26-37, 2007
  5. Kanaan RA, Aldwaik M, Abdelmagid SM, Al-Hanbali OA. The role of connective tissue growth factor in skeletal growth and development. Journal of Medical Science Monitor, 12: 277-281, 2006
  6. Selim AA, Abdelmagid SM, Kanaan RA, Smock SL, Owen TA, Popoff SN, Safadi FF. Anti-Osteoactivin antibody inhibits osteoblast differentiation and function in vitro. Journal of Critical Review in Eukaryotic Gene Expression 13: 265-275, 2003

Manuscripts in Preparation:

  1. Abdelmagid SM, Zajac A, Salhab I, Jones B, Nah H. Pyrophosphates Stimulate Osteoclast Differentiation and Bone Resorption. (In preparation)
  2. Zajac A, Abdelmagid SM, Salhab I, Nah H. Pyrophosphates Modulate Mesenchymal Stem Cell Proliferation and Differentiation. (in preparation)

Publications (Published, But Not Peer Reviewed):

  • Abdelmagid SM, Barbe MF, Rico MC, Salihoglu S, Selim A, Arango-Hisijara I, Anderson MG, John SW, Owen TA, Popoff SN, Safadi FF. Characterization and Functions of Osteoactivin in Osteoblasts. Temple Journal of Orthopaedic Surgery and Sports, 2008. (invited)
  • Abdelmagid SM, Barbe MF, Arango IA, Owen TA, Popoff SN, Safadi FF. Cross-talks between Osteoactivin and BMP-2 in Osteoblast Differentiation. Temple Journal of Orthopaedic Surgery and Sports, 2006. (invited)

Published Abstracts:

  • Hyun-Duck Nah, S. M. Abdelmagid, A. Zajac, S. Imad, M. A. Radecki. The Role of Ank and Inorganic Pyrophosphates in Bone Remodeling and Osteoclastic Activity: Cellular and Molecular Basis of Craniometaphyseal Dysplasia. International Society for Craniofacial Surgery; ISCFS-distraction, Oxford, UK, 2009
  • S.M. Abdelmagid, A. Zajac, I. Salhab, H. Nah. Pyrophosphates Stimulate Osteoclast Differentiation and Bone Resorption. ASBMR 30th Annual Meeting, Montréal, Quebéc, Canada, 2008.
  • J. Y. Belcher, M. C. Rico, I. Arango-Hisijara, S. Salihoglu, K. B. Buck, S.M. Abdelmagid, A. Sanjay, M. C. Nakamura, S. N. Popoff, F. F. Safadi. Bone Cell Autonomous Effects of Osteoactivin/ Gpnmb In Vivo. ASBMR 29th Annual Meeting, Honolulu, Hawaii, 2007.
  • S.M. Abdelmagid, S.L. Kominsky, M. Doucet, K. Brady and K.L. Weber. Production of Bone Resorptive Factors by Renal Cell Carcinoma Bone Metastasis. ASBMR 28th Annual Meeting, Philadelphia, Pennsylvania, 2006.
  • S.M. Abdelmagid, T.A. Owen, S.N. Popoff, F.F. Safadi. Osteoactivin Expression is Regulated by BMP-2 Through Smad-1 Signaling Pathway during Osteoblast Differentiation. ASBMR 27th Annual Meeting, Nashville, Tennessee, 2005.
  • S.M. Abdelmagid, E. Nuglozeh, M.F. Barbe, S.N. Popoff, F.F. Safadi. Regulation of Osteoactivin by Osteotrophic Factors and its Role in Mediating BMP-2 Effects on Osteoblasts Differentiation. ASBMR 26th Annual Meeting, Seattle, Washington, 2004.
  • A.Selim, S.M. Abdelmagid, S.L. Smock, T.A. Owen, S.N. Popoff, F.F. Safadi. The Effects of Modulating Osteoactivin Function on Osteoblast Differentiation. ASBMR 24th Annual Meeting, San Antonio, Texas, 2002

Book Chapters:

  • Safadi FF, Ph.D., Abdelmagid SM, MD. Ph.D., Rico MC, MD., Aswad RA, DDS., Belcher JC, MS, Monroy AM, Ph.D., Litvin J, Ph.D., Sodicoff M, Ph.D., Dela Cadena RA, MD., Daly JM, MD, Popoff SN, Ph.D., Barbe MF, Ph.D. Bone Biology; Development, Structure and Function In: Compendium in Bone Pathology, Editor, Jasvir Khurana, MD. Second edition in press for Humana Press Publisher, 2009.

Unpublished Abstracts and Presentations:

  • S.M. Abdelmagid SM, A. Zajac, I. Salhab, H. Nah. Pyrophosphates Stimulate Osteoclast Differentiation and Bone Resorption. Poster in 19th Annual CHOP Research Conference, Children Hospital of Philadelphia, PA, February 25th, 2009.
  • S.M. Abdelmagid SM, A. Zajac, I. Salhab, H. Nah. Pyrophosphates Stimulate Osteoclast Differentiation and Bone Resorption. Poster in 18th Annual CHOP Research Conference, Children Hospital of Philadelphia, PA, February 27th, 2008.

Presentations at Professional Conferences:

  • S.M. Abdelmagid, A. Zajac, I. Salhab, H. Nah. Pyrophosphates Stimulate Osteoclast Differentiation and Bone Resorption. ASBMR 30th Annual
  • Meeting, Montréal, Quebéc, Canada, September 13th, 2008.
  • S.M. Abdelmagid, S.L. Kominsky, M. Doucet, K. Brady and K.L. Weber, Production of Bone Resorptive Factors by Renal Cell Carcinoma Bone Metastasis. Poster in ASBMR 28th Annual Meeting, Philadelphia, Pennsylvania, September 17th 2006.
  • S.M. Abdelmagid, T.A. Owen, S.N. Popoff, F.F. Safadi. Osteoactivin Expression is Regulated by BMP-2 Through Smad-1 Signaling Pathway during Osteoblast Differentiation. Poster in ASBMR 27th Annual Meeting, Nashville, Tennessee, September 26th 2005.
  • S.M. Abdelmagid, E. Nuglozeh, M.F. Barbe, S.N. Popoff, F.F. Safadi. Regulation of Osteoactivin by Osteotrophic Factors and its Role in Mediating BMP-2 Effects on Osteoblast Differentiation. Poster in ASBMR 26th Annual Meeting, Seattle, Washington, October 2nd 2004.

Honors and Awards

  • 2008 The third prize for poster presentation in the 5th annual scientific symposium for the musculoskeletal disorders, University of Pennsylvania