Lab Fellow

2007-2009
Email Address: gregorylakin@gmail.com

Is a graduate of Duke University and Ponce School of Medicine, and is currently a combined general/plastic surgery resident at the University of Rochester planning to pursue a career in academic microsurgery. During his time in the lab he studied the molecular regulation of palatogenesis, the influence of mechanical stress on Muenke syndrome craniosynstosis, and coordinated the Penn plastic surgery microsurgical skills lab. He is happy to answers questions and may be contacted at gregorylakin@gmail.com

Publications:
Peer-Reviewed Journal Articles:

  1. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PWT, Ballo MT, Chen L, Trent J, Burgess M, Patel S, Pollock RE, Cormier JN. Angiosarcoma of the breast. Cancer. 2005; 104: 2682-2688.
  2. Lakin GE*, Wu C*, Salhab I, Zajac A, Traas J, Dienno JJ, Davis P, Bergelson JM, Zoltick PW, Kirschner RE, Nah HD. Overexpression of IRF6 in the Medial Edge Epithelium of Embryonic Palatal Shelves Rescues the Fusion Defect in a TGF-b3-/- Mouse Palate in Organ Culture. (Manuscript in preparation) *These two authors contributed equally to this work.

Abstracts:

  1. Lakin GE, Zoltick PW, Salhab I, Kallewaard NL, Bergelson JM, Kirschner RE, Nah HD. Overexpression of IRF6 in the Medial Edge Epithelium of Embryonic Palatal Shelves Rescues the Fusion Defect in a TGF-b3-/- Mouse Palate in Organ Culture. Presented at the 19th Annual Children's Hospital of Philadelphia Research Poster Day in Philadelphia, PA, February 25th, 2009.
  2. Robinson DS, Lentz J, Moffat F, Franceschi D, Beber B, Korensky T, Lakin GE. The Role of Stereotactic Mammographically Directed Core Biopsy for Non-Palpable Breast Lesions: A Single Institutional Analysis of 196 Procedures. University of Miami School of Medicine Surgical Oncology and Radiology, Miami, Florida 1995.
  3. Spivak RM, Endo M, Zajac A, Zoltick PW, Lakin GE, Flake AW, Kirschner RE, Nah HD. In Utero Delivery of Virally Encoded TGF-beta3 Rescues Cleft Palate in the TGF-beta3 Knockout Mouse. Presented at the 87th Annual Meeting of the American Association of Plastic Surgeons in Boston, MA, April 5-8, 2008.
  4. Lakin GE, Spivak RM, Zajac A, Dienno JJ, Davis PF, Zoltick PW, Kirschner RE, Nah HD. Adenovirus Encoding the IRF6 Gene Partially Rescues the Fusion Defect in a TGF-beta3-/- Mouse Embryonic Palatal Organ Culture. Presented at the 65th Annual Meeting of the American Cleft Palate-Craniofacial Association in Philadelphia, PA, April 14-18th, 2008.
  5. Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. The Molecular Regulation of Palatogenesis: Adenovirus-Mediated IRF6 Transduction of the Medial Edge Epithelium Rescues the Fusion Defect of the TGF-beta3-/- Mouse Palate in Organ Culture. Presented at the 25th Annual Meeting of the Northeastern Society of Plastic Surgeons in Philadelphia, PA, October 2-5, 2008.
  6. Lakin GE, Dienno, JJ, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Adenoviral Tropism Towards the Medial Edge Epithelium of the Embryonic Mouse Palatal Shelf Correlates with Coxsackievirus and Adenovirus Receptor (CAR) Expression. Accepted to the 66th Annual Meeting of the American Cleft Palate-Craniofacial Association in Scottsdale, AZ, April 20-25, 2009.
  7. Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. Discovery of a New Molecular Pathway in Palatogenesis: IRF6 is an Important Downstream Effector of TGF-beta3 Signaling in Palatal Fusion. Presented at the 88th Annual Meeting of the American Association of Plastic Surgeons in Rancho Mirage, CA, March 21-25, 2009.
  8. Wu C, Radecki A, Lakin GE, Salhab I, Flake AW, Kirschner RE, Nah HD. Intra-amniotic delivery of an adenoviral vector expressing TGFβ3 rescues palatal fusion defect in TGFβ3 null disease models. Presented at the Annual Meeting of the Philadelphia Academy of Surgery in Philadelphia, PA, February 2, 2009.
  9. Lakin GE, Dienno JJ, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Coxsackievirus and Adenovirus Receptor Expression Correlates with Adenoviral Tropism Towards the Embryonic Mouse Palate. Accepted to the 55th Annual Meeting of the Robert H. Ivy Society of Plastic Surgeons in Pittsburgh, PA, April 17-18, 2009.

Book Chapters:

  1. Robinson DS, Sundaram M, Lakin GE. "Carcinoma of the breast in pregnancy and lactation." In Bland KI, Copeland EM (eds): The Breast: A Comprehensive Textbook for the Management of Benign and Malignant Diseases. Second Edition, Philadelphia, WB Saunders, 1998, pp 1433-1445.
  2. Robinson DS, Sundaram M, Lakin GE. "Carcinoma of the breast in pregnancy and lactation." In Bland KI, Copeland EM (eds): The Breast: Comprehensive Management of Benign and Malignant Diseases. Third Edition, Philadelphia, WB Saunders, 2004, pp 1475-1490.

Grants:

  1. Lakin GE, Nah HD, Kirschner RE. "Influence of Mechanical Stress on Muenke Syndrome Craniosynostosis." 2008 Plastic Surgery Educational Foundation Basic Research Grant Award Recipient
  2. Lakin GE, Bartlett S, Nah HD, Kirschner RE. "Influence of Mechanical Stress on the Phenotypic Variability of Muenke Syndrome Craniosynostosis." 2008 American Society of Maxillofacial Surgeons/Maxillofacial Surgeons Foundation & Synthes CMF Research Grant Award Recipient

Protocol:

  • 2008-Present Lakin GE. The Children's Hospital of Philadelphia, The Joseph Stokes, Jr. Research Institute. "Microsurgical Skills Lab using Euthanized Rats" Principle Investigator, Hyun-Duck Nah.

Honors and Awards:

  • 2009 Paul W. Black Junior Investigator Award for best paper presented in the Junior Investigator category at the 66th annual meeting of the American Cleft Palate-Craniofacial Association (ACPA) in Scottsdale, AZ
  • 2008 American Society of Maxillofacial Surgeons/Maxillofacial Surgeons Foundation Research Grant Award
  • 2008 Plastic Surgery Educational Foundation Basic Research Grant Award
  • 2004 Ponce School of Medicine, M.D. with clinical distinction

Professional Memberships:

  • American Society of Plastic Surgeons, Resident Member, 2007-Present
  • American Cleft Palate and Craniofacial Association, Resident Member, 2008-Present
  • American Society for Reconstructive Transplantation, Trainee Member, 2008-Present
  • Northeastern Society of Plastic Surgeons, Resident Member, 2008-Present
  • American Society of Maxillofacial Surgeons, Resident Affiliate Member, 2008-Present
  • Robert H. Ivy Society of Plastic Surgeons, Resident Member, 2009-Present