Hyun-Duck Nah, DMD, PhD

  1. Nah, H.-D., M. Pacifici, L. C. Gerstenfeld, S. L. Adams, and T. Kirsch. 2000. A transient chondrogenic phase in intramembranopus pathway during normal skeletal development. J Bone Min Res 15:522-533.
  2. Nah, H.-D. 2000. Suture Biology: Lessons from molecular genetics of craniosynostosis syndromes. Clin Orthod Res 3:37-45.
  3. Nicozisis, J. L., H.-D. Nah and O.C. Tuncay. 2000. Relaxin affects the dentofacial sutural tissues. Clin Orthod Res 3:192-201
  4. Kirsch, T., B. Swoboda and H.-D. Nah. 2000. Activation of annexin II and V expression, cellular hypertrophy, mineralization and apoptosis in human arthritic cartilage. Osteoarthritis & cartilage, cartilage 8:294-302.
  5. Kirsch, T., G. Harrison, E.E. Golub, and H.-D. Nah. 2000. The role of Annexins, type II and X collagen in matrix vesicle-mediated mineralization of growth plate cartilage. J Biol Chem 275:35577-35583.
  6. Nah, H.-D., B. Swoboda, D. E. Birk, and T. Kirsch. 2001. Type IIA procollagen expression during normal development of limb cartilage; Re-expression of type IIA procollagen in early hypertrophic cartilage and human arthritic articular cartilage. Developmental Dynamics, 220:307-322.
  7. Ratisoontorn C., G.-F. Fan, K. McEntee and H.-D Nah. 2003. Activating (P253R, C278F) and dominant negative mutations of Fgfr2: differential effects on calvarial bone cell proliferation, differentiation and mineralization. Connec Tissue Res, 44: 292-298
  8. Mao JJ, Nah HD. 2004. Growth and development: Hereditary and mechanical modulations. Am J Orthod Dentofacial Orthop 125(6):676-689,.
  9. Fakhry A, Ratisoontorn C, Vedhachalam C, Salhab I, Koyama E, Leboy P, Pacifici M, Kirschner R, Nah HD. Effects of FGF2/9 in calvarial bone cell cultures: Differentiation stage-dependent mitogenic effect, opposite regulation of BMP2 and noggin, and enhancement of osteogenic potential. Bone 36(2):254-266, Feb. 2005.
  10. Choi KY, Kim HJ, Lee MH, Kwon TG, Nah HD, Furuichi T, Komori T, Nam SH, Kim YJ, Kim HJ, Ryoo HM. 2005 Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development. Dev Dyn 233(1):115-121.
  11. Lin, I. C., A.E. Slemp, C. Hwang, M. Sena-Esteves, H,-D. Nah, R.E. Kirschner. 2007. Toward an Understanding of Non-syndromic Craniosynostosis: Dihydrotestosterone stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells and promotes cranial suture fusion in vitro. Plastic Reconstr Surg
  12. Cabiling, D.S., Kim, E., Yan, D., Jacob, S., Nah, HD., Kirschner, RE. Differential Effects of TGF-beta Isoforms on Murine Fetal Dural Cells and Calvarial Osteoblasts. Plast. Reconstr. Surg. In press
  13. Loomes, K.M., Stevens, S.A., O'Brien, M.L., Gonzalez, D.M., Ryan, M.J., Segalov, M., Dormans,N.J., Mimoto, M.S., Gibson, J.D., Sewell, W., Schaffer, A.A., Nah, H.-D, Rappaport, E.F., Pratt, S.C., Dunwoodie, S.L., Kusumi, K. 2007 Dll3 and Notch1 genetic interactions model axial segmental andcraniofacial malformations of human birth defects. Dev Dyn
  14. Lee, K-J, Chen, I-P, Park, K-K, Osyczka, OM, Leboy, PS, Nah, H-D. 2007. FGF9 induction of osteocalcin gene expression requires down-regulation of Msx2 in calvarial osteoblasts. Submitted
  15. Chen IP, Lee KJ, Diefenderfer D, Leboy PS, and Nah HD. 2007. FGF9/FGFR2 Signaling regulates expression and functional activity of Runx2 in disease calvarial osteoblasts. Submitted.

Samir Abdelmagid, M.D., PhD.

  1. Abdelmagid SM, Barbe MF, Rico MC, Salihoglu S, Selim AH, Arango-Hisijara I, Anderson MG, John SW, Owen TA, Popoff SN, Safadi FF. Osteoactivin, an Anabolic Factor that Regulates Osteoblast Differentiation and Function. Journal of Experimental Cell Research, 2008
  2. Barbe MF, Elliott MB, Abdelmagid SM, Safadi FF, Popoff SN, Amin M, Barr AE. Serum and Tissue Cytokines and Chemokines Increase with Performance of Repetitive Upper Extremity Tasks. Journal of Orthopaedic Research, 2008
  3. Kominsky SL, Abdelmagid SM, Doucet M, Brady K, and Weber KL. MIP-1δ: a Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis. Journal of Cancer Research, 68:1261-1266, 2008
  4. Abdelmagid SM, Barbe MF, Arango IA, Owen TA, Popoff SN, Safadi FF. Osteoactivin Acts as Downstream Mediator of BMP-2 Effects on Osteoblast Function. Journal of Cellular Physiology, 210:26-37, 2007
  5. Kanaan RA, Aldwaik M, Abdelmagid SM, Al-Hanbali OA. The role of connective tissue growth factor in skeletal growth and development. Journal of Medical Science Monitor, 12: 277-281, 2006
  6. Selim AA, Abdelmagid SM, Kanaan RA, Smock SL, Owen TA, Popoff SN, Safadi FF. Anti-Osteoactivin antibody inhibits osteoblast differentiation and function in vitro. Journal of Critical Review in Eukaryotic Gene Expression 13: 265-275, 2003

Gregory E. Lakin, M.D.

  1. Lakin GE*, Wu C*, Salhab I, Zajac A, Traas J, Dienno JJ, Davis P, Bergelson JM, Zoltick PW, Kirschner RE, Nah HD. Overexpression of IRF6 Rescues the Tfgb3-/- Mouse Palatal Fusion Defect. (Manuscript in preparation) *These two authors contributed equally to this work.
  2. Robinson DS, Sundaram M, Lakin GE. “Carcinoma of the breast in pregnancy and lactation.” In Bland KI, Copeland EM (eds): The Breast: A Comprehensive Textbook for the Management of Benign and Malignant Diseases. Second Edition, Philadelphia, WB Saunders, 1998, pp 1433-1445.
  3. Robinson DS, Sundaram M, Lakin GE. “Carcinoma of the breast in pregnancy and lactation.” In Bland KI, Copeland EM (eds): The Breast: Comprehensive Management of Benign and Malignant Diseases. Third Edition, Philadelphia, WB Saunders, 2004, pp 1475-1490.
  4. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PWT, Ballo MT, Chen L, Trent J, Burgess M, Patel S, Pollock RE, Cormier JN. Angiosarcoma of the breast. Cancer. 2005; 104: 2682-2688. Abstracts
  5. Robinson DS, Lentz J, Moffat F, Franceschi D, Beber B, Korensky T, Lakin GE. The Role of Stereotactic Mammographically Directed Core Biopsy for Non-Palpable Breast Lesions: A Single Institutional Analysis of 196 Procedures. University of Miami School of Medicine Surgical Oncology and Radiology, Miami, Florida 1995.
  6. Spivak RM, Endo M, Zajac A, Zoltick PW, Lakin GE, Flake AW, Kirschner RE, Nah HD. In Utero Delivery of Virally Encoded TGF-beta3 Rescues Cleft Palate in the TGF-beta3 Knockout Mouse. Presented at the 87th Annual Meeting of the American Association of Plastic Surgeons in Boston, MA, April 5-8, 2008.
  7. Lakin GE, Spivak RM, Zajac A, Dienno JJ, Davis PF, Zoltick PW, Kirschner RE, Nah HD. Adenovirus Encoding the IRF6 Gene Partially Rescues the Fusion Defect in a TGF-beta3-/- Mouse Embryonic Palatal Organ Culture. Presented at the 65th Annual Meeting of the American Cleft Palate-Craniofacial Association in Philadelphia, PA, April 14-18th, 2008.
  8. Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. The Molecular Regulation of Palatogenesis: Adenovirus-Mediated IRF6 Transduction of the Medial Edge Epithelium Rescues the Fusion Defect of the TGF-beta3-/- Mouse Palate in Organ Culture. Presented at the 25th Annual Meeting of the Northeastern Society of Plastic Surgeons in Philadelphia, PA, October 2-5, 2008.
  9. Lakin GE, Dienno, JJ, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Adenoviral Tropism Towards the Medial Edge Epithelium of the Embryonic Mouse Palatal Shelf Correlates with Coxsackievirus and Adenovirus Receptor (CAR) Expression. Accepted to the 66th Annual Meeting of the American Cleft Palate-Craniofacial Association in Scottsdale, AZ, April 20-25, 2009.
  10. Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. Discovery of a New Molecular Pathway in Palatogenesis: IRF6 is an Important Downstream Effector of TGF-beta3 Signaling in Palatal Fusion. Presented at the 88th Annual Meeting of the American Association of Plastic Surgeons in Rancho Mirage, CA, March 21-25, 2009.
  11. Wu C, Radecki A, Lakin GE, Salhab I, Flake AW, Kirschner RE, Nah HD. Intra-amniotic delivery of an adenoviral vector expressing TGFβ3 rescues palatal fusion defect in TGFβ3 null disease models. Presented at the Annual Meeting of the Philadelphia Academy of Surgery in Philadelphia, PA, February 2, 2009.
  12. Lakin GE, Dienno JJ, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD. Coxsackievirus and Adenovirus Receptor Expression Correlates with Adenoviral Tropism Towards the Embryonic Mouse Palate. Accepted to the 55th Annual Meeting of the Robert H. Ivy Society of Plastic Surgeons in Pittsburgh, PA, April 17-18, 2009.

M. Anne Radecki, B.A.

  1. Zajac, A., Baek, S., Salhab, I., Radecki, M.A., Kim, S., and Nah, H. A Novel ANKH Mutation in An Isolated Case of Craniometaphyseal Dysplasia. (2009), American Journal of Medical Genetics, submitted.
  2. Abstract and Podium Presentation at Philadelphia Academy of Surgery, 2009. Wu, C., Radecki, A., Lakin, G., Salhab, I., Flake, A., Kirschner, R., and Nah, H. Intra-amniotic delivery of an adenoviral vector expressing TGF-B3 rescues palatal fusion defect in TGF-B3 null disease models. Awarded Best Resident Paper, Philadelphia Academy of Surgery, 2009.
  3. Rose, A. Y., Radecki, M. A., Hernandez, N. I., Bradley, J. M., Hernandez, M., Acott, T. S., and Kelley, M. J. "Changes in Protein Associations and Phosphorylation with Mechanical Stretch in Trabecular Meshwork Cells." (2001), Investigating Ophthalmology and Visual Science.
  4. Kelley, M. J., Radecki, M. A., Hernandez, N. I., Rookhuizen, D. C., and Acott, T. S. "Signal Transduction in Trabecular Metalloproteinase Regulation." (2000) Experimental Eye Research, 71 S156.
  5. Kelley, M.J., Radecki M. A., Hernandez, N. I., Bradley, J. M, Acott, T. S. "Changes in B3 Integrin Levels and Protein Associations Following Trabecular Cell Mechanical Stretching." (2000), IOVS, 41, S505.

Michael Stosich, DMD, M.S.

  1. Microcomputed Tomograhy of Engineered Vascuolgenesis in Novel Stem Cell-Thrombin Biomatrix
    Writing up for submission
    Michael S. Stosich and Hyun-duck Nah
  2. Facial Reconstruction by Biosurgery: Cell Transplantation Versus Cell Homing
    Regenerative Medicine, in press
    Jeremy J. Mao, Michael S. Stosich, et al
  3. Microscopic Magnetic Resonance Elastography for
    Monitoring Adipogenesis in Tissue-Engineered Construct in vitro.
    Journal of Mag Reson Micr, submitted.
    Michael S. Stosich, Eduardo K Moioli, Nicholas W. Marion, Jeremy J Mao
  4. Bioengineering Strategies to Generate Vascularized Soft Tissue Grafts with Sustained Dimensions.
    Tissue Engineering: Methods Feb 2009
    Michael S. Stosich, Eduardo K Moioli, Jeremy J Mao, et al.
  5. Vascularized Adipose Tissue Grafts from Human Mesenchymal
    Stem Cells with Bioactive Cues and Microchannel Conduits.
    Tissue Engineering, September 2007.
    Michael S. Stosich, Barb Bastian, Nicholas W. Marion,
    Paul A. Clark, Gwendolen Reilly, Jeremy J. Mao
  6. Adipose Tissue Engineering from Adult Human
    Stem Cells: Clinical Implications in Plastic and
    Reconstructive Surgeries.
    Journal of Plastic and Reconstructive Surgery
    Jan;119(1):71-83; discussion 84-5.
    Michael S. Stosich, Jeremy J. Mao
  7. Stem Cells an Option after Reconstructive Surgery
    The Lancet Oncology
    Volume 6, Issue 4, Pages 202-202
    A. Lunec. Review of Michael S. Stosich, Jeremy J. Mao
  8. Stem Cell-Based Soft Tissue Grafts for Plastic
    and Reconstructive Surgeries.
    Seminars in Plastic Surgery, 19:3, 2005.
    Michael S. Stosich, Jeremy J. Mao
  9. Adipogenic Differentiation of Human
    Mesenchymal Stem Cells
    Master of Science Thesis
    University of Illinois at Chicago, The Graduate College
    Michael S. Stosich

Chadwick Wu, M.D.

  1. Wu C, Radecki A, Lakin GE, Salhab I, Flake AW, Kirschner RE, Nah HD. Intra-amniotic delivery of an adenoviral vector expressing TGFβ3 rescues palatal fusion defect in TGFβ3 null disease models. Presented at the Annual Meeting of the Philadelphia Academy of Surgery in Philadelphia, PA, February 2, 2009.

Byung-Ho Yang, D.D.S., Ph.D.

  1. Yang BH, Cha KS. A study on the perimandibular tissues before and after orthodontic treatment with orthognathic surgery in mandibular proganthic patients. Korean Journal of Orthodontics. 30: 261-272, 2000
  2. YB Kim, BH Yang, ZG Piao, SB Oh, JS Kim, K Park. Expression of Na+/HCO3- cotransporter and its role in pH regulation in model parotid acinar cells. Biochemical and Biophysiolocial Research Communications. 304: 593–598, 2003
  3. Yang BH, Piao ZG, Kim YB, Lee CH, Lee JK, Park K, Kim JS, Oh SB. Eugenol may produce its effects by activating a capsaicin receptor in trigeminal ganglion. Journal of Dental Research. 82:781-785, 2003

Hyun-Duck Nah, DMD, PhD
Hyun-Duck Nah, DMD, PhD
Research Director
Craniofacial Research Laboratory
Plastic and Reconstructive Surgery
Children's Hospital of Philadelphia
Lab. Phone: 267-426-5563
Email Address: CraniofacialResearch
@email.chop.edu